Meyer, Stephanie; Haefliger, Joel; Schaefer, Michael; Molloy, John J.; Daniliuc, Constantin G.; Gilmour, Ryan published the artcile< A Chiral Pentafluorinated Isopropyl Group via Iodine(I)/(III) Catalysis>, Product Details of C6H12O3, the main research area is fluoride enantioselective synthesis difluorination trifluoromethyl styrene catalyst; regioselective synthesis difluoronation; agrochemistry; bioisostere; conformation; fluorine; organocatalysis.
An I(I)/(III) catalysis strategy to construct an enantioenriched fluorinated isostere of the iPr group is reported. The difluorination of readily accessible α-CF3-styrenes is enabled by the in situ generation of a chiral ArIF2 species to forge a stereocentre with the substituents F, CH2F and CF3 (up to 95%, >20:1 vicinal:geminal difluorination). The replacement of the metabolically labile benzylic proton results in a highly preorganised scaffold as was determined by X-ray crystallog. (π→σ* and stereoelectronic gauche σ→σ* interactions). A process of catalyst editing is disclosed in which preliminary validation of enantioselectivity is placed on a structural foundation.
Angewandte Chemie, International Edition published new progress about Asymmetric catalysis. 24347-63-5 belongs to class esters-buliding-blocks, and the molecular formula is C6H12O3, Product Details of C6H12O3.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics