Fan, Yi Chiao; Kwon, Ohyun published the artcile< Phosphine/Palladium-Catalyzed Syntheses of Alkylidene Phthalans, 3-Deoxyisoochracinic Acid, Isoochracinic Acid, and Isoochracinol>, Electric Literature of 112-63-0, the main research area is alkylidene phthalan preparation phosphine catalyst Michael palladium catalyst Heck; stereoselective synthesis alkylidene phthalan Michael Heck catalytic.
In this study, we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans, e.g., I (R1 = H, R, R2 = H, OCH2Ph, OMe, CF3, etc., R3 = H, OCH2Ph, OMe, Me, R4 = H, Me, MeO), rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid II (X = none, Y = CO2H) isoochracinic acid II (X = O, Y = CO2H), and isoochracinol II (X = O, Y = CH2OH).
Organic Letters published new progress about Diastereoselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics