Davis, Dexter C.; Mohammad, Haroon; Kyei-Baffour, Kwaku; Younis, Waleed; Creemer, Cassidy Noel; Seleem, Mohamed N.; Dai, Mingji published the artcile< Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus>, Synthetic Route of 112-63-0, the main research area is aryl isonitrile methicillin vancomycin resistant Staphylococcus; Antibiotic; Drug resistance; Isonitrile; MRSA; VRSA.
Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) have emerged as a global health concern. A new class of compounds featuring an aryl isonitrile moiety has been discovered that exhibits potent inhibitory activity against several clin.-relevant MRSA and VRSA isolates. Structure-activity relationship studies have been conducted to identify the aryl isonitrile group as the key functional group responsible for the observed antibacterial activity. The most potent antibacterial aryl isonitrile analogs (MIC 2 μM) did not show any toxicity against mammalian cells up to a concentration of 64 μM.
European Journal of Medicinal Chemistry published new progress about Antibiotics. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics