Brzek, Pawel; Roussel, Damien; Konarzewski, Marek published the artcile< Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is micer basal metabolic rate gut efficient mitochondria; artificial selection; basal metabolic rate; endothermy; laboratory mice; mitochondria; mitochondrial efficiency.
Intra-specific variation in both the basal metabolic rate (BMR) and mitochondrial efficiency (the amount of ATP produced per unit of oxygen consumed) has profound evolutionary and ecol. consequences. However, the functional mechanisms responsible for this variation are not fully understood. Mitochondrial efficiency is neg. correlated with BMR at the interspecific level but it is pos. correlated with performance capacity at the intra-specific level. This discrepancy is surprising, as theories explaining the evolution of endothermy assume a pos. correlation between BMR and performance capacity. Here, we quantified mitochondrial oxidative phosphorylation activity and efficiency in two lines of laboratory mice divergently selected for either high (H-BMR) or low (L-BMR) levels of BMR. H-BMR mice had larger livers and kidneys (organs that are important predictors of BMR). H-BMR mice also showed higher oxidative phosphorylation activity in liver mitochondria but this difference can be hypothesized to be a direct effect of selection only if the heritability of this trait is low. However, mitochondrial efficiency in all studied organs did not differ between the two lines. We conclude that the rapid evolution of BMR can reflect changes in organ size rather than mitochondrial properties, and does not need to be accompanied obligatorily by changes in mitochondrial efficiency.
Proceedings of the Royal Society B: Biological Sciences published new progress about Animal organ, lymphoid. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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