Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Quality Control of 870-50-8.
Winneroski, Leonard L.;Erickson, Jon A.;Green, Steven J.;Lopez, Jose E.;Stout, Stephanie L.;Porter, Warren J.;Timm, David E.;Audia, James E.;Barberis, Mario;Beck, James P.;Boggs, Leonard N.;Borders, Anthony R.;Boyer, Robert D.;Brier, Richard A.;Hembre, Erik J.;Hendle, Jorg;Garcia-Losada, Pablo;Minguez, Jose Miguel;Mathes, Brian M.;May, Patrick C.;Monk, Scott A.;Rankovic, Zoran;Shi, Yuan;Watson, Brian M.;Yang, Zhixiang;Mergott, Dustin J. research published 《 Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints》, the research content is summarized as follows. Inhibition of BACE1 has become an important strategy in the quest for disease modifying agents to slow the progression of Alzheimer’s disease. We previously reported the fragment-based discovery of LY2811376, the first BACE1 inhibitor reported to demonstrate robust reduction of human CSF Aβ in a Phase I clin. trial. We also reported on the discovery of LY2886721, a potent BACE1 inhibitor that reached phase 2 clin. trials. Herein we describe the preparation and structure activity relationships (SAR) of a series of BACE1 inhibitors utilizing trans-cyclopropyl moieties as conformational constraints. The design, details of the stereochem. complex organic synthesis, and biol. activity of these BACE1 inhibitors is described.
Quality Control of 870-50-8, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics