Ester is a chemical compound derived from an oxoacid (organic or inorganic) in which at least one –OH hydroxyl group is replaced by an –O– alkyl (alkoxy) group, 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. as in the substitution reaction of a carboxylic acid and an alcohol. Safety of Diethyl 2-(ethoxymethylene)malonate.
Suryawanshi, M. R.;Dupade, D. D. research published 《 Synthesis and antibacterial activity of some compounds of 1,8- naphthyridine-3-carboxamide》, the research content is summarized as follows. Synthesis and antibacterial evaluation of ten derivatives of naphthyridine-3-carboxamides I [R = 2-Me, 4-F, 3-Cl, etc.] was discussed in this paper. Synthesis of novel 1,8-naphthyridine-3-carboxamide derivatives starting from substituted pyridine with ethoxymethylenemalonate ester by cyclo-condensation reaction afforded 1,8- naphthyridine-3-carboxylates at high temperature and at specific reaction condition. All 1, 8-naphthyridine-3-carboxylate compounds were treated with an excess of substituted anilines with mild reaction conditions. All the compounds obtained were purified by using the recrystallization method. Structure confirmation of synthesized compounds was accomplished on the basis of IR, 1H NMR, and MS. The synthesized compounds were tested against bacterial strain, Escherichia coli (Gram-neg.) Staphylococcus aureus (Gram-pos.). Many of the compounds exhibited significant antibacterial profile.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics