Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 87-13-8, formula is C10H16O5, Name is Diethyl 2-(ethoxymethylene)malonate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Safety of Diethyl 2-(ethoxymethylene)malonate.
Su, Tong;Zhu, Jiongchang;Sun, Rongqin;Zhang, Huihui;Huang, Qiuhua;Zhang, Xiaodong;Du, Runlei;Qiu, Liqin;Cao, Rihui research published 《 Design, synthesis and biological evaluation of new quinoline derivatives as potential antitumor agents》, the research content is summarized as follows. A series of new quinoline derivatives I [R = 3-F, 3-Br, 3,4-di-Cl, etc.; R1 = Cl, EtO, OCH2Ph, etc.] was designed, synthesized and evaluated for their antiproliferative activity. The results demonstrated that compounds I [R = 3-F, 3-MeO, 3-NO2; R1 = O(CH2)7CH3, OCH2Ph, O(CH2)3Ph, 4-FC6H4CH2O] exhibited potent antiproliferative activity with IC50 value of lower than 10 μM against seven human tumor cell lines and compound I [R = 3-MeO; R1 = O(CH2)3Ph] was found to be the most potent antiproliferative agent against HCT-116, RKO, A2780 and Hela cell lines with an IC50 value of 2.56, 3.67, 3.46 and 2.71 μM, resp. The antitumor efficacy of the representative compound I [R = 3-MeO; R1 = O(CH2)3Ph] in mice was also evaluated, and the results showed that compound I [R = 3-MeO; R1 = O(CH2)3Ph] effectively inhibited tumor growth and decreased tumor weight in animal models. Further investigation on mechanism of action indicated that compound I [R = 3-MeO; R1 = O(CH2)3Ph] could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway.
87-13-8, Diethyl ethoxymethylenemalonate is a useful research compound. Its molecular formula is C10H16O5 and its molecular weight is 216.23 g/mol. The purity is usually 95%.
Diethyl ethoxymethylidenemalonate is a matrix effect reagent used in analytical chemistry. It is often used as a substrate for the cycloaddition process, which produces malondialdehyde and hydrochloric acid. The UV-absorption of the malondialdehyde can be measured to determine the concentration of the sample. Diethyl ethoxymethylidenemalonate is also used as a dna template in binding constants, where it binds with amines to form complexes that are then analyzed by light emission. It has been shown to have an inhibitory effect on gyrase and trifluoroacetic acid, both enzymes involved in DNA replication., Safety of Diethyl 2-(ethoxymethylene)malonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics