Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. 870-50-8, formula is C10H18N2O4, Name is Di-tert-butyl diazene-1,2-dicarboxylate. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Category: esters-buliding-blocks.
Ratni, H.;Baumann, K.;Bellotti, P.;Cook, X. A.;Green, L. G.;Luebbers, T.;Reutlinger, M.;Stepan, A. F.;Vifian, W. research published 《 Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer′s disease》, the research content is summarized as follows. Ph rings are one of the most prevalent structural moieties in active pharmaceutical ingredients, even if they often contribute to poor physico-chem. properties. Herein, we propose the use of a bridged piperidine (BP) moiety as a Ph bioisostere, which could also be seen as a superior Ph alternative as it led to strongly improved drug like properties, in terms of solubility and lipophilicity. Addnl., this BP moiety compares favorably to the recently reported saturated Ph bioisosteres. We applied this concept to our γ-secretase modulator (GSM) project for the potential treatment of Alzheimer′s disease delivering clin. candidates.
Category: esters-buliding-blocks, Di-tert-butyl azodicarboxylate, also known as Di-tert-butyl azodicarboxylate, is a useful research compound. Its molecular formula is C₁₀H₁₈N₂O₄ and its molecular weight is 230.26 g/mol. The purity is usually 95%.
Di-tert-butyl azodicarboxylate is a reagent used in the electrophilic amination of β-keto esters catalyzed by an axially chiral guanidine. Building block in an enantioselective synthesis of 3,6-dihyropyridazines employing organocatalysts such a L-proline or (S)-2-pyrrolidinyl tetrazole. Utilized in the asymmetric Friedel-Crafts amination via a chiral organocatalyst.
Di-tert-butyl azodicarboxylate is a reagent used in the preparation of acyl hydrazinedicarboxylates via photoorganocatalytic hydroacylation of dialkyl azodicarboxylates with aldehydes in presence of phenylglyoxylic acid as photocatalyst., 870-50-8.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics