Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Computed Properties of 99769-19-4.
Nguyen, Thuy;Gamage, Thomas F.;Decker, Ann M.;Barrus, Daniel;Langston, Tiffany L.;Li, Jun-Xu;Thomas, Brian F.;Zhang, Yanan research published 《 Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators》, the research content is summarized as follows. Authors previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators which were effective in attenuating cocaine seeking behavior. Herein, authors extended the structure-activity relationships of PSNCBAM-1 I at the central Ph ring directly connected to the urea moiety. Replacement with a thiophene ring led to II with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with non-aromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While compound II had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound II showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.
Computed Properties of 99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., 99769-19-4.
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Ester – Wikipedia,
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