Polyesters are important plastics, with monomers linked by ester moieties. Phosphoesters form the backbone of DNA molecules. 99769-19-4, formula is C8H9BO4, Name is 3-(Methoxycarbonyl)phenylboronic acid.Nitrate esters, such as nitroglycerin, are known for their explosive properties. Reference of 99769-19-4.
Lin, Tingting;Li, Jiacheng;Liu, Liping;Li, Yuanqing;Jiang, Hualiang;Chen, Kaixian;Xu, Pan;Luo, Cheng;Zhou, Bing research published 《 Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors》, the research content is summarized as follows. In this study, a series of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives I (R = Ph, pyridin-3-yl, 2-methyl-5-([3-(morpholin-4-yl)propyl]carbamoyl)phenyl, etc.) was designed, synthesized, and evaluated. The most selective compound I (R = 6-carbamoylpyridin-3-yl) in this series exhibited high potency towards CDK2 and had effective anti-proliferative activity against A2058 melanoma cell line and MV4-11 leukemia cell line while exhibiting low toxic effect on human normal cell lines MRC5 and LX2. The mol. modeling illustrated that compound I (R = 6-carbamoylpyridin-3-yl) had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1. Further biol. studies revealed that compound I (R = 6-carbamoylpyridin-3-yl) suppressed CDK2-associated downstream signaling pathway, blocked cell cycle progression, and induced cellular apoptosis. Therefore, compound I (R = 6-carbamoylpyridin-3-yl) could serve as a potential CDK2 inhibitor for further development.
99769-19-4, 3-Methoxycarbonylphenylboronic acid is a useful research compound. Its molecular formula is C8H9BO4 and its molecular weight is 179.97 g/mol. The purity is usually 95%.
3-Methoxycarbonylphenylboronic acid is a reactanct that has been involved in a variety of applications. For instance, it has been used in Suzuki-Miyaura cross-coupling, Iterative cross-coupling of boronate building blocks, cross-coupling with aryl/ alkenyl sulfonates, synthesis of symmetrical biaryls via CuCl catalyzed homocoupling, trifluoromethylation, and cyanation just to name a few of its many uses.
3-Methoxycarbonylphenylboronic acid is a boronate ligand that has been shown to have an interaction with the nitrogen atoms in amines. This compound is used for the Suzuki coupling reaction, which is a chemical reaction between an organoboron compound and an organic electrophile. 3-Methoxycarbonylphenylboronic acid has a helical structure that can be seen by FTIR spectroscopy and it has potent inhibitory activity., Reference of 99769-19-4
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