Wang, Qian; Chen, Jiean; Huang, Yong published the artcile< Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes>, Computed Properties of 60705-25-1, the main research area is polysubstituted lactone enantioselective synthesis synergistic catalysis ruthenium heterocyclic carbene; synergistic catalysis ruthenium heterocyclic carbene oxidation annulation enal carbonyl; N-heterocyclic carbenes; cooperative effects; oxidation; ruthenium; synergistic catalysis.
Cooperative catalysis combining a transition metal with an N-heterocyclic carbene is challenging due to strong binding of NHCs towards late transition metals. We report the first example of synergistic catalysis by a chiral NHC and a coordinatively unsaturated ruthenium compound RuCl3 was found to mediate efficient aerobic oxidation of homoenolates generated from enals and the N-heterocyclic carbene. The resulting æµ?ç?unsaturated acylazolium intermediate reacts selectively with 1,3-dicarbonyl compounds or ketones at either the ç? or ç»?carbon, yielding polysubstituted chiral lactones in high yield and with excellent enantioselectivity (up to 98 % yield, 94 % ee). This protocol can be applied to structurally sophisticated substrates.
Chemistry – A European Journal published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics