Matador, Esteban; de Gracia Retamosa, Maria; Monge, David; Iglesias-Sigueenza, Javier; Fernandez, Rosario; Lassaletta, Jose M. published the artcile< Bifunctional Squaramide Organocatalysts for the Asymmetric Addition of Formaldehyde tert-Butylhydrazone to Simple Aldehydes>, Electric Literature of 112-63-0, the main research area is bifunctional squaramide organocatalyst asym addition formaldehyde butylhydrazone aldehyde; hydrazones; hydrogen bonds; organocatalysis; solvent effects; squaramides.
The nucleophilic addition of formaldehyde tert-butylhydrazone to simple aldehydes (a formal hetero-carbonyl-ene reaction) can be performed with good reactivity and excellent enantioselectivity by virtue of the dual hydrogen-bonding activation exerted by amide-squaramide organocatalysts. The resulting hydroxydiazenes (azo alcs.) were isolated in high yields as enantiomerically enriched azoxy compounds after a regioselective azo-to-azoxy transformation. Subsequent derivatization provides an entry to relevant amino alcs., oxazolidinones, and derivatives thereof.
Chemistry – A European Journal published new progress about Addition reaction catalysts. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics