Kitabayashi, Nanako; Nakao, Shohei; Mita, Yuichiro; Arisawa, Kotoko; Hoshi, Takayuki; Toyama, Takashi; Ishii, Kiyo-aki; Takamura, Toshinari; Noguchi, Noriko; Saito, Yoshiro published the artcile< Role of selenoprotein P expression in the function of pancreatic ç?cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation>, Product Details of C15H22N2O2, the main research area is pancreatic beta cells ferroptosis cell death; Ferroptosis; GPX4; Pancreatic ç?cells; Selenoprotein K; Selenoprotein P; Stress-induced nascent granule degradation (SINGD).
Selenoprotein P (SELENOP) is a major selenium (Se)-containing protein (selenoprotein) in human plasma that is mainly synthesized in the liver. SELENOP transports Se to the cells, while SELENOP synthesized in peripheral tissues is incorporated in a paracrine/autocrine manner to maintain the levels of cellular selenoproteins, called the SELENOP cycle. Pancreatic ç?cells, responsible for the synthesis and secretion of insulin, are known to express SELENOP. Here, using MIN6 cells as a mouse model for pancreatic ç?cells and Selenop small interfering (si)RNA, we found that Selenop gene knockdown (KD) resulted in decreased cell viability, cellular pro/insulin levels, insulin secretion, and levels of several cellular selenoproteins, including glutathione peroxidase 4 (Gpx4) and selenoprotein K (Selenok). These dysfunctions induced by Selenop siRNA were recovered by the addition of Se. Ferroptosis-like cell death, regulated by Gpx4, was involved in the decrease of cell viability by Selenop KD, while stress-induced nascent granule degradation (SINGD), regulated by Selenok, was responsible for the decrease in proinsulin. SINGD was also observed in the pancreatic ç?cells of Selenop knockout mice. These findings indicate a significant role of SELENOP expression for the function of pancreatic ç?cells by maintaining the levels of cellular selenoproteins such as GPX4 and SELENOK.
Free Radical Biology & Medicine published new progress about Antioxidants. 347174-05-4 belongs to class esters-buliding-blocks, and the molecular formula is C15H22N2O2, Product Details of C15H22N2O2.
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