Behera, Archanamayee; Rai, Diksha; Kulkarni, Suvarn S. published the artcile< Total Syntheses of Conjugation-Ready Trisaccharide Repeating Units of Pseudomonas aeruginosa O11 and Staphylococcus aureus Type 5 Capsular Polysaccharide for Vaccine Development>, Category: esters-buliding-blocks, the main research area is immunotherapy vaccine protecting group stereoselective glycosylation trisaccharide uronate; trisaccharide Pseudomonas aeruginosa preparation stereoselective glycosylation antibiotic fucosamine antigen.
Here, we report the first total synthesis of the conjugation-ready trisaccharide repeating unit of Pseudomonas aeruginosa O11 via a highly stereoselective and efficient assembly of rare L-fucosamine and D-fucosamine containing 1,2-cis linked disaccharide motif and its regioselective glycosylation at O3. A systematic study was conducted for the notoriously difficult glycosylation with the most un-reactive axial 4-OH of the rare disaccharide and the successful outcome was utilized to accomplish the total synthesis of an aminopropyl linker-attached trisaccharide repeating unit of Staphylococcus aureus capsular polysaccharide type 5, which is also a potential antigen for immunotherapy and vaccine development. Judicious selection of protecting groups and reaction conditions allowed the stereoselective assembly and selective functional group inter-conversions to access the structurally complex linker-attached trisaccharide repeating units, which are valuable tools for immunol. evaluation and vaccine development. The strategy is useful for the synthesis of other structurally related complex glycans.
Journal of the American Chemical Society published new progress about Antibiotics. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics