On September 17, 2021, Zhu, Yasheng; Wang, Hongliang; Wang, Gang; Wang, Zehua; Liu, Zhaopeng; Liu, Lei published an article.Safety of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Enantioselective Construction of Single and Vicinal All-Carbon Quaternary Stereocenters through Ion Pair Catalyzed 1,6-Conjugate Addition. And the article contained the following:
An asym. 1,6-conjugate addition to presynthesized δ-aryl-δ-cyano disubstituted para-quinone methides I (R = H, 3-Me, 3-bromo; Ar = Ph, 4-methylphenyl, 2-naphthyl, etc.) through bifunctional phosphonium-amide promoted ion pair catalysis for acyclic all-carbon quaternary stereocenter construction has been described. Both acyclic and cyclic 1,3-dicarbonyls CH2(C(O)OR1)2 (R1 = Ph, 2-methylphenyl, benzyl, etc.)/II (R2 = Me, Et, Bu, allyl) participate in asym. alkylation reaction, furnishing a wide array of diarylmethanes bearing a single acyclic or vicinal cyclic and acyclic quaternary carbon stereocenters III/IV in high efficiency with excellent stereoselectivity. Computational studies elucidate the origin of enantioselectivity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Safety of 3-Acetyldihydrofuran-2(3H)-one
The Article related to cyano hydroxyphenyl aryl methyl propane dicarboxylic ester preparation enantioselective, quinonemethide acyclic dicarbonyl compound conjugate addition phosphonium amide catalyst, cyanohydroxyphenyl aryl methyl oxocyclopentane carboxylic ester preparation enantioselective, cyclic dicarbonyl compound quinonemethide conjugate addition phosphonium amide catalyst and other aspects.Safety of 3-Acetyldihydrofuran-2(3H)-one
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