Xiong, Chenghe; Feng, Shaojie; Qiao, Yin; Guo, Zhongwu; Gu, Guofeng published an article in 2018, the title of the article was Synthesis and Immunological Studies of Oligosaccharides that Consist of the Repeating Unit of Streptococcus pneumoniae Serotype 3 Capsular Polysaccharide.Synthetic Route of 79642-50-5 And the article contains the following content:
A highly convergent and efficient strategy was developed for the chem. synthesis of complex oligosaccharides of Streptococcus pneumoniae type 3 capsular polysaccharides that contain multiple glucuronic acid units. Once the oligo-glucosides were efficiently and stereoselectively assembled, the designated glucose units were regioselectively oxidized to glucuronic acid in one step at the final synthetic stage, which helped avoid difficult glycosylation that involved glucuronic acid. The target oligosaccharides had a free amino group at the reducing terminus and varied caps at the non-reducing terminus to enable further modification and structure-activity relationship studies. Immunol. evaluations of the oligosaccharide-tetanus toxoid conjugates showed that they elicited robust T-cell-dependent IgG antibody responses and that the sugar chain length had a major impact on their immunol. properties. In particular, the penta- and hexasaccharides were identified as promising antigens for vaccine development. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5
The Article related to bovine serum albumin tetanus toxoid glucuronic acid oligosaccharide preparation, structure activity igg antibody glycosylation glucuronic acid oligosaccharide, igg antibody vaccine tetanus toxoid glycosylation glucuronic acid oligosaccharide, oligosaccharide preparation immunol repeating unit streptococcus pneumoniae polysaccharide and other aspects.Synthetic Route of 79642-50-5
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