Wu, Binyu; Wen, Xiaolu; Chen, Hongbing; Hu, Lin published an article in 2021, the title of the article was N-Nosyl-O-bromoethyl hydroxylamine acts as a multifunctional formaldehyde, formaldimine, and 1,2-oxazetidine surrogate for C-C and C-O bond-forming reactions.Application of 10472-24-9 And the article contains the following content:
N-Nosyl-O-bromoethyl hydroxylamine, a bench stable solid, could function as a novel formaldehyde, formaldimine and 1,2-oxazetidine surrogate under DBU basic conditions were described. By merely using this simple reagent, a broad range of synthetically useful β-aminomethyl ketones I [R1 = Me, Ph, 2-furyl, etc.; R2 = Me, Et, allyl, Bn; R1R2 = (CH2)3, (CH2)4, (CH2)5, etc.; R3 = Ac, CO2Me, CO2Et, SO2Ph] and α-hydroxymethyl ketones II [R4 = Me, Et, allyl, Bn; Q = (CH2)n, n = 1,2], as well as chiral α-alkoxyl indanone carboxylates III [R5 = H, 4-MeO, 5-F, etc.; X = OCH2CH2] and α-aminomethyl indanone carboxylates III [X = CH2] could be divergently obtained via chemo- and stereoselective aldol, Mannich or umpolung C-O bond-forming reactions. The challenging catalytic asym. Mannich reaction of formaldimine equivalent was also realized with moderate enantioselectivities. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Application of 10472-24-9
The Article related to aminomethyl ketone preparation, nosyl bromoethyl hydroxylamine benzoyl acetate bond formation, hydroxymethyl ketone preparation, hydroxy ketone nosyl bromoethyl hydroxylamine bond formation, carboxylate indanone hydroxymethyl preparation enantioselective chemoselective, alkoxyl indanone carboxylate preparation enantioselective chemoselective and other aspects.Application of 10472-24-9
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