Sun, Qi; Meng, Xiangju; Liu, Xiao; Zhang, Xiaoming; Yang, Yan; Yang, Qihua; Xiao, Feng-Shou published an article in 2012, the title of the article was Mesoporous cross-linked polymer copolymerized with chiral BINAP ligand coordinated to a ruthenium species as an efficient heterogeneous catalyst for asymmetric hydrogenation.Synthetic Route of 3976-69-0 And the article contains the following content:
Mesoporous ruthenium complexes generated from the copolymer of nonracemic BINAP dioxide bisacrylamide I (or its enantiomer) with divinylbenzene followed by deoxygenation and complexation were prepared as reusable catalysts for chemoselective and enantioselective hydrogenation. In the presence of mesoporous ruthenium complexes generated from the copolymer of I with divinylbenzene, β-keto esters RCOCH2CO2R1 (R = Me, 4-MeOC6H4, ClCH2, Me2CH; R1 = Me, Et, PhCH2, Me3C, Me2CH) were hydrogenated in methanol to the nonracemic β-hydroxy esters II (R = Me, 4-MeOC6H4, ClCH2, Me2CH; R1 = Me, Et, PhCH2, Me3C, Me2CH) in > 99.5% chemoselectivities and conversions and in 91.3-97.7% ee. The surface area of a mesoporous ruthenium complex generated from the copolymer of I and divinylbenzene was determined The mesoporous ruthenium complex generated from the copolymer of I and divinylbenzene was recycled six times in the hydrogenation of Me acetoacetate to give (R)-Me 3-hydroxybutanoate in > 99.5% chemoselectivities and conversions and in 91.3-95.3% ee. Copolymers of other vinyl-functionalized nonracemic ligands with divinylbenzene were prepared; transfer hydrogenation of acetophenone in the presence of a (R,R)-N-(4-vinylphenylsulfonyl)-1,2-diphenyl-1,2-ethanediamine-divinylbenzene copolymer ruthenium complex gave 1-phenylethanol in 94% ee. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Synthetic Route of 3976-69-0
The Article related to mesoporous copolymer binap bisacrylamide ruthenium complex enantioselective hydrogenation catalyst, vinyl functionalized ligand copolymer ruthenium complex enantioselective hydrogenation catalyst, beta hydroxy ester enantioselective preparation, enantioselective hydrogenation beta ketoester binap bisacrylamide copolymer ruthenium complex and other aspects.Synthetic Route of 3976-69-0
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