Sartorius, Frank; Trebing, Marc; Brueckner, Charlotte; Brueckner, Reinhard published an article in 2017, the title of the article was Reducing Diastereomorphous Bis(phosphane oxide) Atropisomers to One Atropisomerically Pure Diphosphane: A New Ligand and a Novel Ligand-Preparation Design.Application of 3976-69-0 And the article contains the following content:
1,1′-Biphenyl-2,2′-diphosphines with an achiral bridge spanning C-5 and C-5′ form atropisomers that are enantiomers. Accessing them in an atropisomerically pure form requires resolving a racemic mixture thereof or of a bis(phosphine oxide) precursor. 1,1′-Biphenyl-2,2′-diphosphines with a homochiral bridge spanning C-5 and C-5′ form atropisomers that are diastereomers. Synthesized the first compound of this kind (1) atropselectively and (2) under thermodn. control-seemingly a first-time exploit in diphosphine synthesis. The selectivity-inducing step was a high-temperature reduction of two non-interconverting bis(phosphine oxide) atropisomers (60:40 mixture). It furnished the desired diphosphine atropisomerically pure (and atropconvergently because the yield was 67 %). This diphosphine proved worthwhile in Tsuji-Trost allylations, the Hayashi addition of phenylboronic acid to cyclohexenone, and the asym. hydrogenation of Me acetoacetate (up to 95 % yield and 95 % ee). The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Application of 3976-69-0
The Article related to diastereomorphous phosphine oxide atropisomer atropisomerically pure diphosphine ligand design, biphenyl diphosphine atropisomer preparation catalyst tsuji trost allylation, hayashi addition phenylboronic acid cyclohexenone biphenyl diphosphine catalyzed, asym hydrogenation methyl acetoacetate biphenyl diphosphine catalyzed and other aspects.Application of 3976-69-0
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