Sable, Ganesh A.; Lee, Kang Ju; Lim, Hyun-Suk published an article in 2019, the title of the article was Solid-phase synthesis and circular dichroism study of β-AB-peptoids.Electric Literature of 3976-69-0 And the article contains the following content:
The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on α-ABpeptoids, oligomers of N-alkylated β2-homoalanines and found that due to the presence of chiral Me groups at α-positions, α-ABpeptoids were shown to adopt folding conformations. Here, we report β-ABpeptoids having chiral Me group at β-positions rather than α-positions as a different class of peptoids with backbone chirality. We developed a facile solid-phase synthetic route that enables the synthesis of β-ABpeptoid oligomers ranging from 2-mer to 8-mer in excellent yields. These oligomers were shown to adopt ordered folding conformations based on CD (CD) and NMR studies. Overall, these results suggest that β-ABpeptoids represent a novel class of peptidomimetic foldamers that will find a wide range of applications in biomedical and material sciences. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Electric Literature of 3976-69-0
The Article related to peptoid beta solid phase synthesis peptidomimetic foldamer cd nmr, chirality peptidomimetic conformation solvent effect, alkyl homoalanine synthesis hydroxybutanate azidation reduction arylation protection, foldamers, peptidomimetics, peptoids, solid-phase synthesis, β-abpeptoids and other aspects.Electric Literature of 3976-69-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics