On December 17, 2021, Ofman, Tim P.; Kuellmer, Florian; van der Marel, Gijsbert A.; Codee, Jeroen D. C.; Overkleeft, Herman S. published an article.Related Products of 2873-29-2 The title of the article was An Orthogonally Protected Cyclitol for the Construction of Nigerose- and Dextran-Mimetic Cyclophellitols. And the article contained the following:
Cyclophellitols are potent inhibitors of exo- and endoglycosidases. Efficient synthetic methodologies are needed to fully capitalize on this intriguing class of mechanism-based enzyme de-activators. We report the synthesis of an orthogonally protected cyclitol from D-glucal (19% yield over 12 steps) and its use in the synthesis of α-(1,3)-linked di- and trisaccharide dextran mimetics. These new glycomimetics may find use as Dextranase inhibitors, and the developed chemistries in widening the palette of glyco-processing enzyme-targeting glycomimetics. The experimental process involved the reaction of (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate(cas: 2873-29-2).Related Products of 2873-29-2
The Article related to epoxidation aziridination trisaccharide dextran mimetic cyclitol nigerose cyclophellitol, oligosaccharide trisaccharide dextran cyclophellitol preparation endoglycosidase inhibitor aziridine, trisaccharide dextran cyclophellitol endoglycosidase glycomimetic dextranase inhibitor glucal cyclitol and other aspects.Related Products of 2873-29-2
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