On May 27, 2013, Markovic, Martin; Duranova, Marianna; Koos, Peter; Szolcsanyi, Peter; Gracza, Tibor published an article.Category: esters-buliding-blocks The title of the article was Synthesis of bis-tetrahydrofuran subunit of (-)-neopallavicinin. And the article contained the following:
The stereospecific Pd/Cu-catalyzed oxycarbonylation of syn/anti-hex-5-ene-2,4-diols I and II was used as a key step in the synthesis of bicyclic lactones III and IV. Eventually, the major intermediate III was transformed to the bis-tetrahydrofuran subunit of naturally occurring diterpenoid (-)-neopallavicinin (V). The target compound VI was thus prepared in 7.5% overall yield over eight steps starting from com. available Me (R)-3-hydroxybutanoate. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Category: esters-buliding-blocks
The Article related to neopallavicinin diterpenoid bistetrahydrofuran subunit preparation, hexenediol palladium copper catalyzed oxycarbonylation, lactone bicyclic bistetrahydrofuran preparation ethylidenation, chiral hydroxybutanoate silylation vinylation, siloxybutanoate chiral preparation vinylation and other aspects.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics