On December 31, 2021, Lin, Han; Hong, Haofei; Feng, Lipeng; Shi, Jie; Zhou, Zhifang; Wu, Zhimeng published an article.Synthetic Route of 79642-50-5 The title of the article was Synthesis of DNP-modified GM3-based anticancer vaccine and evaluation of its immunological activities for cancer immunotherapy. And the article contained the following:
Tumor-associated carbohydrate antigens (TACAs) are attractive targets for vaccine development. In this context, we described a strategy combining artificial TACA and glyco-engineering for cancer vaccine development. A 2,4-ditrophenyl (DNP)-modified GM3 intermediate was synthesized chemo-enzymically and conjugated to keyhole limpet hemocyanin (KLH), and the resulting bioconjugate was tested for its potential as a vaccine candidate. Mice immunol. studies revealed that the DNP-modified GM3 (GM3-NHDNP) analog elicited strong and rapid immune responses by recruiting anti-DNP antibodies to facilitate the targeted delivery of the vaccine construct to antigen processing cells (APCs). Moreover, the endogenously produced anti-DNP antibodies, together with the elicited antibodies against GM3-NHDNP, may synergistically promote tumor binding and cancer cell death when the cancer cell surfaces are glycoengineered to express the GM3-NHDNP antigen. The experimental process involved the reaction of Bis(2,5-dioxopyrrolidin-1-yl) glutarate(cas: 79642-50-5).Synthetic Route of 79642-50-5
The Article related to ifn il6 igg igm sialooligosaccharide preparation apoptosis, human serum albumin bioconjugate sialooligosaccharide preparation sialic aldolase, keyhole limpet hemocyanin bioconjugate vaccine tumor associated carbohydrate antigen, dnp gm3 sialooligosaccharide preparation antitumor antigen vaccine antibody prodrug and other aspects.Synthetic Route of 79642-50-5
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