On August 15, 2020, Hussain, Javeena; Chhabria, Dimple; Kirubakaran, Sivapriya published an article.Product Details of 707-07-3 The title of the article was Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors. And the article contained the following:
Ras is a small family of GTPases that control numerous cellular functions like cell proliferation, growth, survival, gene expression, and is closely engaged in cancer pathogenesis. The ras-targeted methodol. entails a holy grail in oncol. Nevertheless, there are no specific mols. reported targeting the same, although it is a known oncogene for more than three decades. In this study, we have designed and synthesized new phosphate derivatives of Myo-inositol to inhibit the oncogenic KRAS pathway in breast cancer cells, which has been validated by cellular and theor. studies. The synthesized compound I (C2-O-phosphate derivative of myo-inositol 1,3,5-orthobenzoate) inhibited the downstream signaling pathway of oncogenic KRAS, RAF/MEK/ERK. Furthermore, we also found that this compound induced necrosis/apoptosis and causes cell cycle arrest. This class of mols. may work as a potential inhibitor of breast cancer caused by a mutation in KRAS and its downstream proteins. Though the efficacy of the mols. is in the micromolar scale, they have not been explored previously for RAS inhibition. Impressive preliminary results are presented in this article which could be further explored for its detailed biol. studies to get better candidates as RAS inhibitors. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Product Details of 707-07-3
The Article related to gene expression inositol benzoate synthesis mol docking kras, ras inhibition gtpase cell proliferation crystal structure human, antitumor inositol cyclitol preparation breast cancer necrosis apoptosis kras, antiproliferative activity, breast cancer, kras, molecular docking, myo-inositol and other aspects.Product Details of 707-07-3
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