On April 5, 2021, Hayrapetyan, Davit; Stepanova, Valeriya published an article.Formula: C6H8O3 The title of the article was Facile Synthesis of Spirocyclic Lactams via [3+2] and [3+3] Aza-Annulation Reactions. And the article contained the following:
Spirocyclic pyrrolidones and piperidones such as I and II were synthesized starting from readily available α-ketolactones and α-ketolactams employing [3+2]- and [3+3]-aza-annulation reactions. Tandem reactions of enamino lactams and lactones with maleic and itaconic anhydride yielded alkylidenespirolactams in good yields; further reduction of the exocyclic C=C double bond of the enamino moiety proceeded with excellent diastereoselectivity. Overall, one C-C and two C-N bonds, as well as three new stereocenters were created in a diastereoselective manner resulting in a fast upbuild of mol. complexity. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Formula: C6H8O3
The Article related to pyrrolidinone piperidinone spirolactam diastereoselective preparation, tandem michael addition cyclization maleic itaconic anhydride aminoalkylidene lactam, stereoselective cyclization maleic itaconic anhydride aminoalkylidene lactam, reduction stereoselective alkylidene spirolactam and other aspects.Formula: C6H8O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics