On June 10, 2004, Fujimoto, Roger Aki; McQuire, Leslie Wighton; Monovich, Lauren G.; Mugrage, Benjamin Biro; Parker, David Thomas; Van Duzer, John Henry; Wattanasin, Sompong published a patent.Formula: C12H14F3NO2 The title of the patent was Preparation of substituted amino phenylacetic acids and derivatives and their use as cyclooxygenase-2 (COX-2) inhibitors. And the patent contained the following:
The title compounds I (R = H, alkyl, cycloalkyl, halo, alkoxy, F3CO, Me3C, cyano, R1 = biaryl, β-naphthyl derivative, bicyclic heterocyclic aryl, cycloalkyl monocyclic carbocyclic aryl, cycloalkane fused-monocyclic carbocyclic aryl) were prepared Thus, N,N-dimethyl-2-(2′,3′,5′,6′-tetrafluoro-4′-phenylanilino)phenylacetamide was hydrolyzed to give I (R = H, R1 = 4-PhC6F4). The experimental process involved the reaction of tert-Butyl (4-(trifluoromethyl)phenyl)carbamate(cas: 141940-37-6).Formula: C12H14F3NO2
The Article related to phenylacetic acid amino preparation cyclooxygenase 2 inhibitor, rheumatoid arthritis inhibitor aminophenylacetic acid, osteoarthritis inhibitor aminophenylacetic acid, dysmenorrhea inhibitor aminoophenylacetic acid, pain inhibitor aminophenylacetic acid, neoplasm inhibitor aminophenylacetic acid, inflammation inhibitor aminophenylacetic acid and other aspects.Formula: C12H14F3NO2
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