On June 15, 2015, Duss, Michael; Capolicchio, Samanta; Linden, Anthony; Ahmed, Nisar; Jessen, Henning J. published an article.Application of 707-07-3 The title of the article was Desymmetrization of myo-inositol derivatives by lanthanide catalyzed phosphitylation with C2-symmetric phosphites. And the article contained the following:
Desymmetrization by phosphorylation represents a promising method with potential impact in many different areas of research. C2-Sym. phosphoramidites have been used to desymmetrize myo-inositol derivatives by functionalization at different positions. With this method, 1:1 mixtures of diastereomers are obtained that can be separated subsequently. In this work, activation of a C2-sym. phosphoramidite is achieved by addition of pentafluorophenol (PFP) and leads to a reactive PFP phosphite, which can then be coupled to protected myo-inositol derivatives with reactive OH groups at the 1, 3, 4 and 6 positions. This strategy enhances the diastereoselectivity of the coupling reaction with a preference towards phosphitylation at position 6 (up to 3:1) or position 3 (up to 2:1). The concept of activation of phosphoramidites via in situ generated pentafluorophenol phosphite triesters is thus proven in these studies. It is further shown that Lewis-Acid catalysis enhances the rate of phosphite triester coupling without affecting the diastereoselectivity. This novel strategy improves access to different phosphorylated myo-inositol derivatives and will thus enable further studies into the function of these important intracellular second messengers. The experimental process involved the reaction of (Trimethoxymethyl)benzene(cas: 707-07-3).Application of 707-07-3
The Article related to pentafluorophenol coupling phosphoramidite pentafluorophenol catalysis inositol intracellular messenger, inositol desymmetrization lanthanide catalyzed phosphitylation phosphorylation phosphoramidite cyclitol, chiral auxiliary, diphosphoinositol polyphosphates, inositol, phosphite, phosphorylation and other aspects.Application of 707-07-3
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