On September 15, 2005, Constan, Alexander A.; Keshary, Prakash; Maclean, David B.; Paralkar, Vishwas M.; Roman, Doina; Thompson, David D.; Wright, Timothy M. published a patent.Electric Literature of 142327-44-4 The title of the patent was Preparation of heterocyclic compounds as EP2 selective receptor agonists for treating pulmonary hypertension and other conditions. And the patent contained the following:
The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using the compounds I [A = SO2, CO; G = Ar, Ar(alkylene), ArCONH(alkylene), etc.; B = N, CH; Q = alkylene, X(alkylene), X(alkylene), etc.; Z = carboxy, alkoxycarbonyl, tetrazolyl, etc.; K = a bond, alkylene, thioalkylene, etc.; M = Ar3, Ar4SAr5, Ar4OAr5, etc.; Ar, Ar3-Ar5 = partially saturated or fully unsaturated 5-8 membered ring having 1-4 heteroatoms selected from O, S, N, or a bicyclic ring, tricycling ring, etc.; X = X = 5-6 membered aromatic ring optionally having 1-2 heteroatoms selected from O, N and S], an EP2 selective receptor agonists. Syntheses of representative compounds I and their intermediates are described in several examples. E.g., a 3-step synthesis of 7-[(4-butylbenzyl)-(pyridine-3-sulfonyl)amino]heptanoic acid, starting from Me 7-aminoheptanoate (preparation given) and 4-butylbenzaldehyde, was given. The compounds I were tested for binding to prostaglandin E2 receptors (data given for exemplified compounds I). The experimental process involved the reaction of Methyl 2-(3-formylphenyl)acetate(cas: 142327-44-4).Electric Literature of 142327-44-4
The Article related to heterocyclic compound ep2 receptor agonist therapeutic antihypertensive, pulmonary hypertension treatment ep2 receptor agonist heterocyclic compound, thiophenecarboxylate preparation ep2 receptor agonist therapeutic antihypertensive, pyridinesulfonylaminomethylphenylacetate preparation ep2 receptor agonist therapeutic antihypertensive and other aspects.Electric Literature of 142327-44-4
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