On October 1, 2018, Akcha, Selma; Gomez-Ruiz, Santiago; Kellou-Tairi, Safia; Lezama, Luis; Perez, Frank Blanco; Benali-Baitich, Ouassini published an article.Safety of 3-Acetyldihydrofuran-2(3H)-one The title of the article was Synthesis, characterization, solution equilibria, DFT study, DNA binding affinity and cytotoxic properties of a cobalt(II) complex with a 5-pyrazolone ligand. And the article contained the following:
The authors’ work describes the synthesis, the complexation and the characterization of a cobalt(II) complex with a 5-pyrazolone ligand carrying a thioamide group on N1 position. The study of the complexation in solution allowed the determination of the stability constants of the complex and the distribution of the species involving Co(II) over the whole pH-range. The solid cobalt(II) complex has then been synthesized and fully characterized by IR, electronic, EPR and mass spectrometries, in addition to magnetic and voltammetric measurements. The data clearly indicated an octahedral high spin Co(II) complex with two mononeg. mols. of the N,S-ligand, and two water mols., likely in a cis position because of the high anisotropy. DFT calculations performed on both the ligand and the complex structures allowed the authors to study the spectral features, and to propose the most fitting structures to the exptl. data. The interaction of the 5-pyrazolone ligand and its cobalt(II) complex with fish-sperm DNA has been studied by electronic spectrometry and cyclovoltammetry. Intercalation has been identified as a binding mode and the strength of the binding assessed. In order to explore eventual cytotoxic and/or cytostatic properties of the authors’ compounds, the ligand and the cobalt complex have been tested on PC-3 (human prostate carcinoma) and HT-29 (human colon carcinoma) using sulforhodamine B (SRB) assay. The experimental process involved the reaction of 3-Acetyldihydrofuran-2(3H)-one(cas: 517-23-7).Safety of 3-Acetyldihydrofuran-2(3H)-one
The Article related to cobalt carbothioamidepyrazolone aqua complex preparation formation constant, magnetic property optimized mol structure cobalt carbothioamidepyrazolone aqua complex, electrochem dna binding cobalt carbothioamidepyrazolone aqua complex, antitumor activity cobalt carbothioamidepyrazolone aqua complex and other aspects.Safety of 3-Acetyldihydrofuran-2(3H)-one
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