Carry, Jean-Christophe; Clerc, Francois; Minoux, Herve; Schio, Laurent; Mauger, Jacques; Nair, Anil; Parmantier, Eric; Le Moigne, Ronan; Delorme, Cecile; Nicolas, Jean-Paul; Krick, Alain; Abecassis, Pierre-Yves; Crocq-Stuerga, Veronique; Pouzieux, Stephanie; Delarbre, Laure; Maignan, Sebastien; Bertrand, Thomas; Bjergarde, Kirsten; Ma, Nina; Lachaud, Sylvette; Guizani, Houlfa; Lebel, Remi; Doerflinger, Gilles; Monget, Sylvie; Perron, Sebastien; Gasse, Francis; Angouillant-Boniface, Odile; Filoche-Romme, Bruno; Murer, Michel; Gontier, Sylvie; Prevost, Celine; Monteiro, Marie-Line; Combeau, Cecile published the artcile< SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases>, Related Products of 252932-48-2, the main research area is SAR156497 antitumor Aurora kinase.
The Aurora family of serine/threonine kinases is essential for mitosis. Their crucial role in cell cycle regulation and aberrant expression in a broad range of malignancies have been demonstrated and have prompted intensive search for small mol. Aurora inhibitors. Indeed, over 10 of them have reached the clinic as potential anticancer therapies. We report herein the discovery and optimization of a novel series of tricyclic mols. that has led to SAR156497, an exquisitely selective Aurora A, B, and C inhibitor with in vitro and in vivo efficacy. We also provide insights into its mode of binding to its target proteins, which could explain its selectivity.
Journal of Medicinal Chemistry published new progress about Antitumor agents. 252932-48-2 belongs to class esters-buliding-blocks, and the molecular formula is C7H10N2O2, Related Products of 252932-48-2.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics