In 2022,Zare Davijani, Neda; Kia-Kojoori, Reza; Abdolmohammadi, Shahrzad; Sadegh-Samiei, Sepehr published an article in Molecular Diversity. The title of the article was 《Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity》.Electric Literature of C5H6O2 The author mentioned the following in the article:
In this research, authors synthesized the Fe3O4/CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N-methylimidazole, alkyl bromides, activated acetylenic compounds and 2-aminoacetonitrile at ambient temperature for the production of new cyanopyrroloazepine derivatives in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized cyanopyrroloazepines have NH groups in their structure and for this reason have good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed some cyanopyrroloazepines antimicrobial effect. The results showed that synthesized cyanopyrroloazepine prevented the bacterial growth. This used process for preparation of new cyanopyrroloazepine has some improvements such as low reaction time, product with high yields, simple separation of catalyst and products. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Electric Literature of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics