Yamamoto, Takeshi; Suzuki, Yuka; Ito, Emi; Tokunaga, Etsuko; Shibata, Norio published the artcile< Asymmetric Synthesis of Both Mirror Images of 3'-Fluorothalidomide by Enantiodivergent Fluorination Using a Single, Cinchona Alkaloid>, COA of Formula: C19H34O2, the main research area is dihydroquinine phthalimidopiperidinone fluorination; fluorothalidomide enantioselective preparation.
Enantiomerically pure 3′-fluorothalidomide (I) was successfully synthesized by enantiodivergent electrophilic fluorination using a combination of cinchona alkaloids and N-fluorobenzenesulfonimide (NFSI) as the key reaction. Importantly, a single chiral mol., dihydroquinine (DHQ), allowed access to the mirror image form of 3′-fluorothalidimide by the choice of additives. While the use of TMEDA gave fluorinated (S)-II, the precursor of I, with 78% ee, Cu(acac)2/bipy, afforded the antipode, (R)-II, in 77% ee.
Organic Letters published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics