《NaClO2-mediated preparation of pyridine-2-sulfonyl chlorides and synthesis of chiral sulfonamides》 was published in Journal of Sulfur Chemistry in 2020. These research results belong to Xu, Dong; Yang, Shiyi; Gao, Aijun; Yang, Zhanhui. Application In Synthesis of H-Trp-OMe.HCl The article mentions the following:
A simple method to prepare azaarenesulfonyl chlorides by NaClO2-mediated oxidative chlorination of azaarenethiols with water as the solvent has been developed. Easy purification by simple extraction and concentration gave the products in good yields. The azaarenesulfonyl chlorides readily underwent condensation with chiral amines to afford chiral sulfonamides. In the experiment, the researchers used many compounds, for example, H-Trp-OMe.HCl(cas: 7524-52-9Application In Synthesis of H-Trp-OMe.HCl)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Application In Synthesis of H-Trp-OMe.HCl
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