《Tetrahydropyridines’ Stereoselective Formation, How Lockdown Assisted in the Identification of the Features of Its Mechanism》 was published in Molecules in 2022. These research results belong to Vereshchagin, Anatoly N.; Iliyasov, Taigib M.; Karpenko, Kirill A.; Akchurin, Radmir N.; Minyaev, Mikhail E.. COA of Formula: C6H10O3 The article mentions the following:
The multicomponent reaction of aldehydes, cyano-containing C-H acids, esters of 3-oxocarboxylic acid and ammonium acetate led to unexpected results. The boiling of starting materials in methanol for one to two hours resulted in the formation of polysubstituted 1,4,5,6-tetrahydropyridines with two or three stereogenic centers. During the 2020 lockdown,key intermediates of the six-step domino reaction was obtained. A number of fast and slow reactions occurred during the prolonged stirring of the reaction mass at rt. Sequence: 1.Knoevenagel condensation; 2.Michael addition; 3.Mannich reaction; 4. cyclization-fast reactions and cyclization of the product polysubstituted 2-hydroxypiperidine-was isolated after 40 min stirring at rt. Further monitoring proved the slow dehydration of 2-hydroxypiperidine to obtain 3,4,5,6-tetrahydropyridine after 7 days. Then, four-month isomerization occurred with 1,4,5,6-tetrahydropyridine formation. All reactions were stereoselective. Key intermediates and products structures were verified by X-ray diffraction anal. Addnl.,conditions for the selective intermediates prepn was specified.Methyl 3-oxovalerate(cas: 30414-53-0COA of Formula: C6H10O3) was used in this study.
Methyl 3-oxovalerate(cas: 30414-53-0) belongs to ketone compounds. Ketone compounds have important physiological properties. They are found in several sugars and in compounds for medicinal use, including natural and synthetic steroid hormones. Molecules of the anti-inflammatory agent cortisone contain three ketone groups.COA of Formula: C6H10O3
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