Singh, Ravi P.; Aziz, Marian N.; Gout, Delphine; Fayad, Walid; El-Manawaty, May A.; Lovely, Carl J. published the artcile< Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies>, Name: 4-tert-Butylphenylisothiocyanate, the main research area is imino methoxybenzylidene thiazolidine thiazolidinone preparation antiproliferative human QSAR; 2D-QSAR; HCT-116; One-pot; Tandem reaction.
A series of N-substituted (Z)-2-imino-(5Z)-ylidene thiazolidines and (Z)-2-imino-(5Z)-ylidene thiazolidin-4-ones were synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) cancer cell lines were evaluated utilizing an MTT growth assay. A 2D-QSAR investigation was conducted to probe and validate the obtained antiproliferative properties for the thiazolidine derivatives The majority of the thiazolidines exhibit higher potency against a colon cancer cell line relative to the standard reference The p-halophenylimino p-anisylidene derivatives exhibited the highest anti-proliferative activity against HCT116 relative to control (IC50 = 8.9-10.0μM compared to 20.4μM observed for 5-fluorouracil as pos. control). An X-ray study confirmed the Z,Z’-configurations for two examples of the synthesized compounds
Bioorganic & Medicinal Chemistry published new progress about Amines, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 19241-24-8 belongs to class esters-buliding-blocks, and the molecular formula is C11H13NS, Name: 4-tert-Butylphenylisothiocyanate.
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