Shanthamurthy, Chethan D.; Kikkeri, Raghavendra published the artcile< Linear Synthesis of De novo Oligo-Iduronic Acid>, Synthetic Route of 34637-22-4, the main research area is oligoiduronic acid synthesis IdoA glycosaminoglycan iduronic conformational plasticity.
L-Iduronic acid (IdoA) plays a pivotal role in glycosaminoglycan (GAG) protein interactions. However, the structural microheterogeneity of GAG appears to impede the systematic investigation of IdoA functions. Under such conditions, oligo-Iduronic acid (Oligo-IdoA) are ideal and straightforward heparin mimetics to unravel the relationship between IdoA structure and functions. Herein, we report for the first-time linear synthesis of rare oligo-IdoA precursor utilizing anhydrous β-L-idopyranosyl and IdoA thiophenol building block. After screening various synthetic strategies, we have installed successive IdoA by 5 step reactions with 25-26 % overall yield. These oligo-IdoA are expected to be excellent probes to understand conformational plasticity of IdoA and fine tune carbohydrate-protein interactions.
European Journal of Organic Chemistry published new progress about Glycosaminoglycans Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Synthetic Route of 34637-22-4.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics