The author of 《Late-stage peptide C-H alkylation for bioorthogonal C-H activation featuring solid phase peptide synthesis》 were Schischko, Alexandra; Kaplaneris, Nikolaos; Rogge, Torben; Sirvinskaite, Giedre; Son, Jongwoo; Ackermann, Lutz. And the article was published in Nature Communications in 2019. Computed Properties of C10H10O2 The author mentioned the following in the article:
Methods for the late-stage diversification of structurally complex peptides hold enormous potential for advances in drug discovery, agrochem. and pharmaceutical industries. While C-H arylations emerged for peptide modifications, they are largely limited to highly reactive, expensive and/or toxic reagents, such as silver(I) salts, in superstoichiometric quantities. In sharp contrast, we herein establish the ruthenium(II)-catalyzed C-H alkylation on structurally complex peptides. The additive-free ruthenium(II)carboxylate C-H activation manifold is characterized by ample substrate scope, racemization-free conditions and the chemo-selective tolerance of otherwise reactive functional groups, such as electrophilic ketone, bromo, ester, amide and nitro substituents. Mechanistic studies by experiment and computation feature an acid-enabled C-H ruthenation, along with a notable protodemetalation step. The transformative peptide C-H activation regime sets the stage for peptide ligation in solution and proves viable in a bioorthogonal fashion for C-H alkylations on user-friendly supports by means of solid phase peptide syntheses. In addition to this study using Benzyl acrylate, there are many other studies that have used Benzyl acrylate(cas: 2495-35-4Computed Properties of C10H10O2) was used in this study.
Benzyl acrylate(cas: 2495-35-4) is a reagent that can be used in the preparation of 2-(Phosphonomethyl)pentanedioic Acid, a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor. It can also be used in the preparation of high refractive index polyacrylates.Computed Properties of C10H10O2
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