Scalzo, Rebecca L.; Schauer, Irene E.; Rafferty, Deirdre; Knaub, Leslie A.; Kvaratskhelia, Nina; Johnson, Taro Kaelix; Pott, Gregory B.; Abushamat, Layla A.; Whipple, Mary O.; Huebschmann, Amy G.; Cree-Green, Melanie; Reusch, Jane E. B.; Regensteiner, Judith G. published the artcile< Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes>, SDS of cas: 112-63-0, the main research area is skeletal muscle oxidative flux diabetes human exercise training; blood flow; diabetes; exercise; skeletal muscle.
Cardiorespiratory fitness is impaired in type 2 diabetes (T2D), conferring significant cardiovascular risk in this population; interventions are needed. Previously, we reported that a T2D-associated decrement in skeletal muscle oxidative flux is ameliorated with acute use of supplemental oxygen, suggesting that skeletal muscle oxygenation is rate-limiting to in vivo mitochondrial oxidative flux during exercise in T2D. We hypothesized that single-leg exercise training (SLET) would improve the T2D-specific impairment in in vivo mitochondrial oxidative flux during exercise. Adults with (n = 19) and without T2D (n = 22) with similar body mass indexes and levels of phys. activity participated in two weeks of SLET. Following SLET, in vivo oxidative flux measured by 31P-MRS increased in participants with T2D, but not people without T2D, measured by the increase in initial phosphocreatine synthesis (P = 0.0455 for the group × exercise interaction) and maximum rate of oxidative ATP synthesis (P = 0.0286 for the interaction). Addnl., oxidative phosphorylation increased in all participants with SLET (P = 0.0209). After SLET, there was no effect of supplemental oxygen on any of the in vivo oxidative flux measurements in either group (P > 0.02), consistent with resolution of the T2D-associated oxygen limitation previously observed at baseline in subjects with T2D. State 4 mitochondrial respiration also improved in muscle fibers ex vivo. Skeletal muscle vasculature content and calf blood flow increased in all participants with SLET (P < 0.0040); oxygen extraction in the calf increased only in T2D (P = 0.0461). SLET resolves the T2D-associated impairment of skeletal muscle in vivo mitochondrial oxidative flux potentially through improved effective blood flow/oxygen delivery. Journal of Physiology (Oxford, United Kingdom) published new progress about Blood vessel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.
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