Reihani, Neda; Kiyani, Hamzeh published their research in Current Organic Chemistry in 2021. The article was titled 《Three-component Synthesis of 4-Arylidene-3-alkylisoxazol-5(4H)-ones in the Presence of Potassium 2,5-dioxoimidazolidin-1-ide》.Category: esters-buliding-blocks The article contains the following contents:
An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones I (R = Me, Et, propyl; Ar = 4-dimethylaminophenyl, 2-thienyl, 3-indolyl, etc.) has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes ArCHO with hydroxylamine hydrochloride and β-ketoesters RC(O)CH2C(O)OCH2CH3. The potassium 2,5-dioxoimidazolidin-1-ide II has been introduced as the new organocatalyst to facilitate this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes ArCHO, hydroxylamine hydrochloride, and Et acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used to synthesize the number of substituted isoxazole- 5(4H)-ones I in good to high yields in ethylene glycol as a green reaction medium at 80°C. The low catalyst loading is also a main advantage over some reported catalysts. The experimental process involved the reaction of Ethyl 3-oxopentanoate(cas: 4949-44-4Category: esters-buliding-blocks)
Ethyl 3-oxopentanoate(cas: 4949-44-4) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics