In 2022,Peng, Ting; He, Yujiao; Wang, Tao; Yu, Jialing; Ma, Xiaofang; Zhou, Zongyuan; Sheng, Yuwen; Li, Lingyu; Peng, Huipan; Li, Sheng; Zou, Jiawei; Yuan, Yi; Zhao, Yongyun; Shi, Hailong; Li, Fu; Liu, Wanli; Hu, Kaifeng; Lu, Xiaoxia; Zhang, Guolin; Wang, Fei published an article in Journal of Medicinal Chemistry. The title of the article was 《Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis》.Recommanded Product: 4949-44-4 The author mentioned the following in the article:
MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small mols. targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we identified a small mol., CIB-3b (I), which suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells. Mechanistically, CIB-3b phys. binds to transactivation response (TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction, thereby altering the activity of Dicer and mature miRNA production Structure-activity relationship study via the synthesis of 45 CIB-3b derivatives showed that some compounds exhibited a similar inhibitory effect on miRNA biogenesis to CIB-3b. These results support TRBP as a potential therapeutic target in HCC and warrant further development of CIB-3b along with its analogs as a novel therapeutic strategy for the treatment of HCC. In addition to this study using Ethyl 3-oxopentanoate, there are many other studies that have used Ethyl 3-oxopentanoate(cas: 4949-44-4Recommanded Product: 4949-44-4) was used in this study.
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Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics