In 2019,Organic Letters included an article by Martinez-Mingo, Mario; Rodriguez, Nuria; Gomez Arrayas, Ramon; Carretero, Juan C.. Electric Literature of C12H15ClN2O2. The article was titled 《Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives》. The information in the text is summarized as follows:
A general method for the construction of seven-membered rings through Pd-catalyzed C(sp2)-H carbonylation at the remote ε-position of γ-arylpropylamine derivatives, including chiral α-amino acids, was developed using Mo(CO)6 as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives The readily removable N-SO2Py protecting/directing group provides high levels of chemo-, regio- and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex mols. such as small peptides. In the experiment, the researchers used H-Trp-OMe.HCl(cas: 7524-52-9Electric Literature of C12H15ClN2O2)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Electric Literature of C12H15ClN2O2
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