Manfrin, Alessandro; Hanggli, Aline; van den Wildenberg, Jeroen; McNeill, Kristopher published the artcile< Substituent Effects on the Direct Photolysis of Benzotrifluoride Derivatives>, Name: Methyl 3-(trifluoromethyl)benzoate, the main research area is benzotrifluoride derivative direct photolysis substituent effect.
The chem. class of benzotrifluoride derivatives is widely used in active ingredients of various com. products, such as pharmaceuticals, pesticides, herbicides, and crop protection agents. Past studies have shown that some benzotrifluorides are not stable under UV irradiation in water and convert into benzoic acids due to C-F bond hydrolysis. It was also observed, but never systematically studied, that the ring substituents play an important role on the direct photochem. reactivity of the CF3 moiety. In the present work, we explore the structure-reactivity relationship between ring substituent and direct photodefluorination for 16 different substituents, by determining fluoride production rates, quantum yields, and half-lives, and found that strong electron-donating groups enhance the reactivity toward hydrolysis. In addition, flufenamic acid, travoprost, dutasteride, cyflumetofen, flutoanil, and teriflunomide were also examined, finding that their direct photochem. reactivity could be qual. predicted based on their ring substituents. We provide here a tool to evaluate the environmental persistence of benzotrifluoride contaminants, as well as to design more photodegradable new active ingredients.
Environmental Science & Technology published new progress about Defluorination. 2557-13-3 belongs to class esters-buliding-blocks, and the molecular formula is C9H7F3O2, Name: Methyl 3-(trifluoromethyl)benzoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics