In 2013,Maiti, Barnali; Chanda, Kaushik; Selvaraju, Manikandan; Tseng, Chih-Chung; Sun, Chung-Ming published 《Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation》.ACS Combinatorial Science published the findings.Reference of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:
A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodol. facilitates the rapid generation of intricate mol. frameworks in three-dimensional fashion leading to benzimidazole-imidazo[1,2-a]pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biol. interesting compounds The present synthetic sequence permits the introduction of three points of structural diversity to expand chem. space with high purity and excellent yields. In addition to this study using Methyl 4-fluoro-3-nitrobenzoate, there are many other studies that have used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Reference of Methyl 4-fluoro-3-nitrobenzoate) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Reference of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics