In 2019,Organic Chemistry Frontiers included an article by Liu, Zhaohong; Raveendra Babu, Kaki; Wang, Feng; Yang, Yang; Bi, Xihe. Computed Properties of C5H6O2. The article was titled 《Influence of sulfonyl substituents on the decomposition of N-sulfonylhydrazones at room temperature》. The information in the text is summarized as follows:
A detailed study of the dissociation performance of structurally varied N-sulfonylhydrazones was described and N-tfsylhydrazone was proved to be the best substrate to give the corresponding diazo compound R1C(N2)R2 [R1 = Ph, 2-FC6H4, 2,4-di-ClC6H3, etc.; R2 = H, Me, Ph] at room temperature N-tfsylhydrazone was capable of releasing non-stabilized aryldiazomethane in a wide range of solvents in the presence of various commonly used bases under mild reaction conditions (-25° to 40°). The utility of the strategy was established by late-stage derivatization of bioactive mols. and several typically sensitive reactions, in which highly purified diazo compounds were required. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Computed Properties of C5H6O2)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Computed Properties of C5H6O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics