Liu, Yang; Ruan, Hanying; Li, Ying; Sun, Guoliang; Liu, Xiao; He, Wenhui; Mao, Fengfeng; He, Miaomiao; Yan, Liwei; Zhong, Guocai; Yan, Huan; Li, Wenhui; Zhang, Zhiyuan published an article in 2021. The article was titled 《Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue》, and you may find the article in Journal of Medicinal Chemistry.Synthetic Route of C4H8O3 The information in the text is summarized as follows:
Analogs of the natural product cyclosporine A (CsA) were developed and assessed as antivirals against infection of hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). An analog termed 27A exhibits potent inhibition of HBV/HDV infection by specifically blocking viral engagement to its cellular receptor NTCP, while it lacks immunosuppressive activity found in natural CsA. I.p. injection or oral intake of 27A protects HDV-susceptible mouse model from HDV infection. 27A serves as a promising lead for the development of novel anti-HDV/HBV agents. The experimental process involved the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Synthetic Route of C4H8O3)
Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Synthetic Route of C4H8O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics