In 2018,Lee, Yun-Ta; Chiu, Feng-Yu; Barve, Indrajeet J.; Sun, Chung-Ming published 《Microwave-assisted synthesis of benzimidazole-linked indoline and indole hybrids from C-2 linked (o-aminobenzyl)benzimidazoles》.Advanced Synthesis & Catalysis published the findings.Application of 329-59-9 The information in the text is summarized as follows:
An efficient and novel synthesis of benzimidazole-linked indoline hybrids I [R1 = H, (CH2)3CH3, (CH2)2Ph, etc.; R2 = Me, Ph, 4-HOC6H4, 4-MeOC6H4, 4-O2NC6H4, 1,3-benzodioxol-5-yl; R3 = H, Me, Ph; R2R3 = (CH2)4; R4 = H, 7-Me, 5-CF3, 5-C(O)OMe] via an unconventional Pictet-Spengler-type condensation of C-2 linked (o-aminobenzyl)benzimidazoles with aldehydes and ketones under microwave irradiation was explored. Addnl., benzimidazole-linked indoline hybrids were further converted into the corresponding benzimidazole-linked indole hybrids II [R5 = CH2CH(CH3)2, (CH2)3CH3; R6 = Ph, 4-MeOC6H4, 4-O2NC6H4] by oxidation utilizing DDQ as oxidizing agent and the desired products were obtained in excellent yields. The key condensation step consisted acid-catalyzed imine generation followed by intramol. C-C bond formation through unique reactivity of the benzimidazole moiety. The scope of this method was further extended to synthesize tetracyclic pyrroloindole benzimidazole-carboxylates through 2-carboxaldehydes.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Application of 329-59-9) was used in this study.
Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Application of 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics