In 2022,Kozma, Viktoria; Szollosi, Gyorgy published an article in Molecular Catalysis. The title of the article was 《Conjugate addition of 1,3-dicarbonyl compounds to maleimides using bifunctional primary amine-(thio)phosphoramide organocatalysts》.Category: esters-buliding-blocks The author mentioned the following in the article:
Asym. Michael additions of 1,3-dicarbonyl compounds to N-substituted maleimides were carried out using primary amine-(thio)phosphoramide bifunctional chiral organocatalysts derived from optically pure C2-sym. 1,2-diamines. The addition of Et 2-fluoroacetoacetate using the 1,2-diphenylethane-1,2-diamine derived thiophosphoramide catalyst afforded various succinimides substituted with fluorine bearing quaternary carbon in high yields, good diastereomeric ratios and excellent enantiomeric excesses. Alicyclic β-ketoesters provided the diastereomerically pure Michael adducts in good yields and high enantioselectivities, whereas 2,4-pentanedione afforded products with slightly lower enantiomeric excesses. The bulkiness of the N-substituent of the maleimide ring influenced mostly the conversions. The thiophosphoramide catalyst was found also efficient in the addition of Et 2-fluoroacetoacetate to β-nitrostyrenes. Unprecedentedly, during this work the highly enantioselective addition of 1,3-dicarbonyl compounds to maleimides were catalyzed by a primary amine-hydrogen-bond donor groups containing bifunctional organocatalyst. These reactions occurred through enamine intermediate, as evidenced by electrospray-ionization mass spectrometry and NMR spectroscopy. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)
Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Category: esters-buliding-blocks
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics