Formula: C12H15ClN2O2In 2021 ,《Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones》 appeared in Synthesis. The author of the article were Khalili Foumeshi, Maryam; Ziyaei Halimehjani, Azim; Alaei, Ali; Klepetarova, Blanka; Beier, Petr. The article conveys some information:
Thiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeded via a domino alkylation/intramol. Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions. The results came from multiple reactions, including the reaction of H-Trp-OMe.HCl(cas: 7524-52-9Formula: C12H15ClN2O2)
H-Trp-OMe.HCl(cas:7524-52-9) is one of amino acid derivatives. Amino acid derivatives represent an important category of skin penetration promoters. These compounds possess hydrophobic chains attached to an amino acid headgroup via a biodegradable ester bond. Due to the amphiphilic nature of these derivatives, it is possible for them to enter into the SC lipid barrier and significantly disorganize skin membrane lipids.Formula: C12H15ClN2O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics