In 2019,Biosensors & Bioelectronics included an article by Khadka, Roshan; Aydemir, Nihan; Carraher, Colm; Hamiaux, Cyril; Colbert, Damon; Cheema, Jamal; Malmstrom, Jenny; Kralicek, Andrew; Travas-Sejdic, Jadranka. Related Products of 119-36-8. The article was titled 《An ultrasensitive electrochemical impedance-based biosensor using insect odorant receptors to detect odorants》. The information in the text is summarized as follows:
Herein, we present that insect odorant receptors reconstituted into the lipid bilayers of liposomes can be successfully immobilized onto a gold surface and selectively and sensitively detect odorant mols. The odorant receptors (OrXs) Or10a, Or22a, and Or71a from the common fruit fly, Drosophila melanogaster, were recombinantly expressed, purified and integrated into nano-liposomes (100-200 nm). These liposomes were covalently attached to the self-assembled monolayers (SAMs) of a 6-mercaptohexanoic acid (MHA)-modified gold surface. X-ray Photo Electron Spectroscopy (XPS) and Quartz Crystal Microbalance with Dissipation (QCM-D) measurements confirmed the successful modification of the gold surface and immobilization of liposomes. Atomic Force Microscopy (AFM) revealed that the liposomes were covalently attached to the surface without any disruption of vesicles. The liposomes tethered to the gold sensor surface were then treated with a range of known ligands of various concentrations We demonstrated by Electrochem. Impedance Spectroscopy (EIS) that an OrX/liposome EIS sensor can sensitively and selectively detect its known ligand to femtomolar concentrations by detecting a change in elec. signal upon binding. Our study is the first step towards using purified insect odorant receptors alone in biosensors to enable the development of novel ultrasensitive volatile sensors for medical diagnostic, air quality, food safety and border security applications. After reading the article, we found that the author used Methyl Salicylate(cas: 119-36-8Related Products of 119-36-8)
Methyl Salicylate(cas: 119-36-8) has been used: as a component of clarifying solution for treating Mongolian gerbil cochlea intact for immunofluorescence analysis, as a plant elicitor to test its effect on reducing the whitefly population from tomato plants.Related Products of 119-36-8
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Ester – an overview | ScienceDirect Topics