Reference of Ethyl propiolateIn 2020 ,《Domino Reaction for the Synthesis of Polysubstituted Pyrroles and Lamellarin R》 was published in Journal of Organic Chemistry. The article was written by Hwu, Jih Ru; Roy, Animesh; Panja, Avijit; Huang, Wen-Chieh; Hu, Yu-Chen; Tan, Kui-Thong; Lin, Chun-Cheng; Hwang, Kuo-Chu; Hsu, Ming-Hua; Tsay, Shwu-Chen. The article contains the following contents:
Treatment of α-silylaryl triflates, Schiff bases, and alkynes was generated polysubstituted pyrroles in good yields (61-86%) with regioselectivity. This domino reaction involved completion of five sequential steps in a single flask, which comprised aryne formation through 1,2-elimination, their alkylation by Schiff bases through 1,2-addition, 1,4-intramol. proton transfer, Huisgen 1,3-dipolar cycloaddition, and dehydrogenative aromatization. It was then successfully applied as the key step in the synthesis of the natural product lamellarin R. This new reaction represented an efficient, sustainable process for the production of chem. materials. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)
Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Reference of Ethyl propiolate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics